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The connection between glycolysis and PD involves the enzyme phosphoglycerate kinase 1 (PGK1), the first ATP-producing enzyme in the glycolytic pathway, encoded by the PGK1 gene

Studies have revealed metabolic heterogeneity across different disease phases and clinical subtypes

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It mainly occurs in the liver, and it may, therefore, be altered during liver tumorigenesis

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Meanwhile, PGC-1 expression and oxygen consumption decreases when exposed to TNF- in tubular cells, whereas excessive PGC-1 reverses the latter effect